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Test for celiac disease - genetic

Q: How are tests for celiac disease performed?

The genetic test for celiac disease tests specific HLA genes (HLA-DQ2 and HLA-DQ8) from the blood, associated with the occurrence of the disease. The serological test for gluten intolerance tests the blood for antibodies against tissue transglutaminase and deamidated gliadin peptide.

Q: How do I know if I have celiac disease?

At Unilabs, you can undergo a genetic test for celiac disease , which tests for specific HLA genes (DQ2 and DQ8) that are associated with the disease. You can also undergo a serological test for gluten intolerance , which tests for IgA and IgG antibodies .

Q: When can celiac disease manifest?

Celiac disease can occur at any age and manifests itself in different ways. In children under 3 years of age, the typical manifestation is the so-called malabsorption syndrome, i.e. insufficient absorption of nutrients in the small intestine. In older children, intestinal symptoms are less noticeable and in adulthood, extraintestinal symptoms come to the fore ( 6 ).

Q: What does celiac disease stool look like?

Celiac disease stool is often light yellow, bulky, greasy, and foul-smellin g, all due to undigested fats and food debris. It is difficult to pass and the urge to defecate occurs 3 to 4 times a day.

Q: How much do celiac disease tests cost?

At Unilabs, we offer a genetic test for celiac disease from blood for 80 euros . We offer a serological test for celiac disease (gluten intolerance) from blood for 50,70 euros .

Q: How does gluten intolerance manifest itself?

Gluten intolerance (also celiac disease) is an autoimmune disease in which the body reacts to gluten, a protein found in wheat, rye and barley. Typical symptoms include diarrhea or constipation, bloating, abdominal pain, intestinal bleeding, but also fatigue, nervousness, headache or weight loss due to nutrient deficiencies.

Q: What is the difference between celiac disease and gluten allergy?

Gluten (wheat) allergy is an excessive immune system reaction to gluten mediated by IgE or non-IgE antibodies and is associated with rapidly occurring unpleasant symptoms after consuming a specific type of food containing gluten, e.g. wheat, but not other gluten grains. Celiac disease (gluten intolerance) is an autoimmune disease, the immune system reacts abnormally to gluten and causes inflammation and damage to the small intestine.

Q: How to detect gluten intolerance?

The easiest and most effective way is to undergo a gluten intolerance test, both genetic and serologica l, in which we will determine both the hereditary predisposition to the development of the disease, as well as the (ab)presence of antibodies against the gluten-digesting enzyme. You will receive the test result within 15 working days.

Q: What does celiac disease stool look like?

The symptoms of celiac disease are generally variable and there is no clear definition of a typical “celiac” stool. Some patients may also have constipation, but diarrhea is more common, when the stool is watery and loose, may also be oily and bulky, is difficult to flush, and may have an unpleasant odor.

Q: How do I know if I have gluten intolerance?

At Unilabs, we have prepared for you a genetic and a serological test for gluten intolerance, which will reveal whether a hereditary predisposition or the presence of antibodies in the serum is behind long-lasting digestive problems.

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80 €

Digestive problems such as loss of appetite, abdominal discomfort, nausea, straining to vomit, bloating, and loud bowel movements can be overlooked for some time. However, with more frequent occurrence and in connection with other symptoms (occasional diarrhea or constipation), they may indicate a hitherto hidden serious digestive disorder - celiac disease. It is far from manifesting itself only in childhood, but more and more often we come across it only in adulthood.

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About this test

Genetic testing for susceptibility to celiac disease can predict this often strange and vaguely manifested, but hereditary disorder based on hereditary dispositions. Thanks to this, not only treatment, but also nutritional measures are directed effectively. We recommend that you undergo an affordable and painless examination, even if you do not have any of the specific symptoms. Celiac disease is always hereditary, which means that the risk does not only apply to you, but also to your relatives. However, it may not manifest itself in other family members. Not everyone who carries risk alleles may develop celiac disease (1).

Why get a genetic test for celiac disease

Untreated celiac disease can lead to the development of, for example, type 1 diabetes, multiple sclerosis, infertility and bowel cancer (2). By taking a simple test, you will gain an overview of your health and you can prevent the risk of developing other diseases.
You can undergo genetic testing for celiac disease, even if you have already eliminated gluten from your diet. However, the blood test can be falsely negative if you decide to stop gluten before taking it.
Celiac disease is a genetic autoimmune disease, which means it runs in families. If you have celiac disease, there is a 1 in 10 chance that another family member will develop it (3). A careful genome analysis will help you uncover the genetic load in your family history.
As part of the celiac disease test, we examine the human leukocyte antigen (HLA – Human Leukocyte Antigen) genes, which are estimated to be involved in the genetic susceptibility to celiac disease in up to 40% of cases (4).
You will receive the test result within 15 working days.

Notice

The definitive diagnosis is determined by a physician, based on further examinations.

If you require consultation regarding the results of the intolerance package, we recommend seeking guidance from a clinical immunologist and allergist.

What’s inside

Test for celiac disease - genetic

What’s measured

About celiac disease

Celiac disease is a systemic disease of genetically predisposed individuals, causing permanent intolerance to gluten, which is found in cereals including wheat, rye and barley. The cause of the disease is an abnormal reaction of the immune system to gluten components, which causes damage to the small intestine; specifically villi lining the small intestine and supporting the absorption of nutrients. When the villi are damaged, nutrients cannot be absorbed properly (11).

It has been proven that genes of the main histocompatibility complex (MHC II), which in humans is called HLA (Human Leukocyte Antigen), have an influence on genetic predisposition. The latter is involved in the genetic susceptibility to celiac disease in up to 40% of cases. However, the presence of risk genes does not necessarily mean that celiac disease will develop. About 25 to 30% of the population have HLA alleles, but only 1% actually develop the disease.

A non-invasive and painless test for celiac disease that requires only a blood sample, examines specific genetic alleles DQA1*02, DQA1*03, DQA1*05, DQB1*02, DQB1*0302, DRB1*04 and detects serological equivalents of HLA-DQ2 (DQ2 .5, DQ2.2) and HLA-DQ8 (12). It will reveal not only the genetic background of celiac disease, but also the transmission of the disease within the family, which is especially useful if you already have symptoms of celiac disease. Given that most people with confirmed celiac disease (99%) have one of the HLA-DQ2/DQ8 alleles, the test is particularly suitable for ruling out a predisposition to celiac disease. A negative test result means that you are very unlikely to develop celiac disease in your lifetime (13).

When is it appropriate to take a celiac disease test?

If you repeatedly experience:

bloating,
chronic diarrhea,
constipation,
flatulence,
lactose intolerance (often lactose intolerance or poor absorption of fructose occurs at the same time as gluten intolerance; when the condition of the intestinal mucosa improves after stopping gluten, lactose intolerance also disappears in most cases) (14),
thin, greasy, bulky and smelly stools,
nausea or vomiting,
abdominal pain.

Remember that not all symptoms of celiac disease are related to the digestive system. Dermatitis herpetiformis (a rare autoimmune skin disease closely related to celiac disease), fatigue, joint or bone pain, headaches, balance problems, seizures or peripheral neuropathy, reproductive problems in both women and men, ulcers and canker sores may also occur. mouth or red, smooth and shiny tongue (5).

What else you should know about celiac disease before you get tested

Specific symptoms of celiac disease (abdominal pain and swelling, chronic diarrhea alternating with constipation, vomiting, weight loss and irritability) develop only in a fraction of patients, asymptomatic celiac disease is also becoming more common according to studies (6). Already in 2002, Swiss research found that almost 1% of examined asymptomatic adolescents without risk factors had celiac disease (7). The idea that the absence of symptoms means you don't have celiac disease is wrong. Remember that patients with celiac disease have a 3- to 10-fold higher risk of developing another autoimmune disease (8).

We have already informed you about the strong association between celiac disease and the human leukocyte antigen (HLA) genes. The main genes associated with celiac disease are HLA-DQ2 (specifically HLA-DQ2.5 and HLA-DQ2) and HLA-DQ8, which are found in almost all patients with celiac disease (99%) (9). The main benefit of genetic testing (professionally called HLA typing) is the exclusion of the diagnosis if specific HLA alleles are missing (thus reducing the risk of celiac disease to < 1%) (10).

Positive HLA testing is not diagnostic of celiac disease; it just indicates that further investigation is needed. The advantage of the genetic examination is also that HLA typing needs to be done "only once", because a person's genotype does not change.

Instructions before collection

Please, only make an appointment for the examination Blood test to detect colorectal cancer between Monday and Thursday. Please, also do not make an appointment for collection on days preceding public holidays. If you make an appointment on a Friday or on a day before a public holiday, we will contact you and your appointment will be changed to another date by mutual agreement.

The result of the genetic test is not affected by adherence to a gluten-free diet. Peripheral blood collection does not need to be performed while fasting and can be performed at any time of the day. The result of the test is not affected by the use of any medications, diets or smoking.

Sources

(1) Celiac disease screening | Celiac Disease Foundation. (n.d.). Celiac Disease Foundation. Dostupné online na: https://celiac.org/about-celiac-disease/screening-and-diagnosis/screening/. [cit. 18-08-2024].

(2) Cdf. (2021). 9 reasons you should be tested for Celiac disease | Celiac Disease Foundation. Celiac Disease Foundation. Dostupné online na: https://celiac.org/2016/09/01/9-reasons-you-should-be-tested-for-celiac-disease/. [cit. 18-08-2024].

(3) Coeliac disease fact sheet 2023. (n.d.). Coeliac UK. Dostupné online na: https://www.coeliac.org.uk/document-library/6995-coeliac-disease-fact-sheet-2023/. [cit. 18-08-2024].

(4) King, A. L., & Ciclitira, P. J. (2000). Celiac disease: strongly heritable, oligogenic, but genetically complex. Molecular Genetics and Metabolism, 71(1–2), 70–75. Dostupné online na: https://doi.org/10.1006/mgme.2000.3067. [cit. 18-08-2024].

(5) Symptoms & Causes of Celiac Disease. (2022). National Institute of Diabetes and Digestive and Kidney Diseases. Dostupné online na: https://www.niddk.nih.gov/health-information/digestive-diseases/celiac-disease/symptoms-causes. [cit. 18-08-2024].

(6) Castillejo, G., Ochoa-Sangrador, C., Pérez-Solís, D., Cilleruelo, M. L., Donat, E., García-Burriel, J. I., Sánchez-Valverde, F., Garcia-Calatayud, S., Eizaguirre, F. J., Martinez-Ojinaga, E., Barros, P., Leis, R., Salazar, J. C., Barrio, J., Peña-Quintana, L., Luque, V., Polanco, I., Ribes, C., & Roman, E. (2023). Coeliac Disease Case–Control Study: Has the Time Come to Explore beyond Patients at Risk? Nutrients, 15(5), 1267. Dostupné online na: https://doi.org/10.3390/nu15051267. [cit. 18-08-2024].

(7) Rutz, R., Ritzler, E., & Herzog, D. (2002). Prevalence of asymptomatic celiac disease in adolescents of eastern Switzerland. Schweizerische Medizinische Wochenschrift. Dostupné online na: https://doi.org/10.4414/smw.2002.09793. [cit. 18-08-2024].

(8) Bibbò, S., Pes, G. M., Usai-Satta, P., Salis, R., Soro, S., Colosso, B. M. Q., & Dore, M. P. (2017). Chronic autoimmune disorders are increased in coeliac disease. Medicine, 96(47), e8562. Dostupné online na: https://doi.org/10.1097/md.0000000000008562. [cit. 18-08-2024].

(9) Anderson, R. P., Henry, M. J., Taylor, R., Duncan, E. L., Danoy, P., Costa, M. J., Addison, K., Tye-Din, J. A., Kotowicz, M. A., Knight, R. E., Pollock, W., Nicholson, G. C., Toh, B., Brown, M. A., & Pasco, J. A. (2013). A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways. BMC Medicine, 11(1). Dostupné online na: https://doi.org/10.1186/1741-7015-11-188. [cit. 18-08-2024].

(10) Tye‐Din, J. A., Cameron, D. J. S., Daveson, A. J., Day, A. S., Dellsperger, P., Hogan, C., Newnham, E. D., Shepherd, S. J., Steele, R. H., Wienholt, L., & Varney, M. D. (2015). Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective. Internal Medicine Journal, 45(4), 441–450. Dostupné online na: https://doi.org/10.1111/imj.12716. [cit. 18-08-2024].

(11) What is Celiac Disease? | Celiac Disease Foundation. (n.d.). Celiac Disease Foundation. Dostupné online na: https://celiac.org/about-celiac-disease/what-is-celiac-disease/. [cit. 18-08-2024].

(12) M, S., F, F., F, G., C, B., G, L., F, D. M., & Gl, D. A. (2018). Genetic susceptibilty and celiac disease: what role do HLA haplotypes play? PubMed, 89(9-S), 17–21. Dostupné online na: https://doi.org/10.23750/abm.v89i9-s.7953. [cit. 18-08-2024].

(13) Suchy, F. J., Brannon, P. M., Carpenter, T. O., Fernandez, J. R., Gilsanz, V., Gould, J. B., Hall, K., Hui, S. L., Lupton, J., Mennella, J., Miller, N. J., Osganian, S. K., Sellmeyer, D. E., & Wolf, M. A. (2010). National Institutes of Health Consensus Development Conference: Lactose Intolerance and Health. Annals of Internal Medicine, 152(12), 792. Dostupné online na: https://doi.org/10.7326/0003-4819-152-12-201006150-00248. [cit. 18-08-2024].

(14) Čr, Ú. (n.d.). Nesnášenlivost lepku, celiakie. NZIP.cz. Dostupné online na: https://www.nzip.cz/clanek/360-nesnasenlivost-lepku-celiakie. [cit. 18-08-2024].

What interests you about the Genetic test for celiac disease?

How are tests for celiac disease performed?

The genetic test for celiac disease tests specific HLA genes (HLA-DQ2 and HLA-DQ8) from the blood, associated with the occurrence of the disease. The serological test for gluten intolerance tests the blood for antibodies against tissue transglutaminase and deamidated gliadin peptide.

How do I know if I have celiac disease?

At Unilabs, you can undergo a genetic test for celiac disease, which tests for specific HLA genes (DQ2 and DQ8) that are associated with the disease. You can also undergo a serological test for gluten intolerance, which tests for IgA and IgG antibodies.

When can celiac disease manifest?

Celiac disease can occur at any age and manifests itself in different ways. In children under 3 years of age, the typical manifestation is the so-called malabsorption syndrome, i.e. insufficient absorption of nutrients in the small intestine. In older children, intestinal symptoms are less noticeable and in adulthood, extraintestinal symptoms come to the fore (6).

What does celiac disease stool look like?

Celiac disease stool is often light yellow, bulky, greasy, and foul-smelling, all due to undigested fats and food debris. It is difficult to pass and the urge to defecate occurs 3 to 4 times a day.

How much do celiac disease tests cost?

At Unilabs, we offer a genetic test for celiac disease from blood for 80 euros. We offer a serological test for celiac disease (gluten intolerance) from blood for 50,70 euros.

How does gluten intolerance manifest itself?

Gluten intolerance (also celiac disease) is an autoimmune disease in which the body reacts to gluten, a protein found in wheat, rye and barley. Typical symptoms include diarrhea or constipation, bloating, abdominal pain, intestinal bleeding, but also fatigue, nervousness, headache or weight loss due to nutrient deficiencies.

What is the difference between celiac disease and gluten allergy?

Gluten (wheat) allergy is an excessive immune system reaction to gluten mediated by IgE or non-IgE antibodies and is associated with rapidly occurring unpleasant symptoms after consuming a specific type of food containing gluten, e.g. wheat, but not other gluten grains. Celiac disease (gluten intolerance) is an autoimmune disease, the immune system reacts abnormally to gluten and causes inflammation and damage to the small intestine.

How to detect gluten intolerance?

The easiest and most effective way is to undergo a gluten intolerance test, both genetic and serological, in which we will determine both the hereditary predisposition to the development of the disease, as well as the (ab)presence of antibodies against the gluten-digesting enzyme. You will receive the test result within 15 working days.

What does celiac disease stool look like?

The symptoms of celiac disease are generally variable and there is no clear definition of a typical “celiac” stool. Some patients may also have constipation, but diarrhea is more common, when the stool is watery and loose, may also be oily and bulky, is difficult to flush, and may have an unpleasant odor.

How do I know if I have gluten intolerance?

At Unilabs, we have prepared for you a genetic and a serological test for gluten intolerance, which will reveal whether a hereditary predisposition or the presence of antibodies in the serum is behind long-lasting digestive problems.

Customer reviews

5 stars out of 3 ratings

3 Customer reviews

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Eva · 5/5

Verified customer

Odporúčam.

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View answer from Unilabs Online 🧡

Ďakujeme za odporúčanie. :)

05.09.2024

Monika · 5/5

Verified customer

všetko v poriadku, výsledky prišli do 15 dní ako bolo uvedené

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Veľmi pekne Vám ďakujeme za pozitívnu spätnú väzbu. :)

08.08.2024

Darina · 5/5

Verified customer

Odber prebehol v poriadku, zobrali ma načas. Výsledky mi prišli o 3 dni. Super.

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Ďakujeme Vám za pozitívne hodnotenie :)

22.07.2024

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