About this test
If you experience digestive issues after consuming foods containing gluten or if your parents suffer from congenital gluten enteropathy (coeliac disease) or lactose intolerance, this test is suitable for you. Genetic diseases often have a familial pattern, however, not all carriers of specific genes inevitably develop the associated disease. The presence of specific genes is just one aspect of the factors contributing to the development of the disease.
Why take a genetic test for celiac disease?
- A total of 3 parameters measured
- Results within 15 working days
- With the results, you can possibly adjust your diet
- A genetic test for celiac disease can determine if your digestive problems, such as bloating, cramps, diarrhea or gas, are caused by an inability to digest gluten.
- It identifies the presence of genes associated with gluten intolerance
At what symptoms to take the test?
The following are typical symptoms of food intolerance:
- Flatulence (bloating), abdominal pain
- Vomiting, cramps, diarrhoea
- Loss of appetite, weight loss
The testing package comprises three genetic tests designed to detect the presence of genes associated with intolerance to gluten, lactose, and fructose.
Notice
The definitive diagnosis is determined by a physician, based on further examinations.
If you require consultation regarding the results of the intolerance package, we recommend seeking guidance from a clinical immunologist and allergist.
What’s inside
Test for celiac disease - genetic
What’s measured
Celiac disease or gluten intolerance
Coeliac disease is a systemic condition characterised by an immune system response occurring in genetically predisposed individuals. It results in a lasting intolerance of the immune system to gluten, a protein present in various grains such as wheat, rye, and barley. The disease is caused by an abnormal activation of the immune system, leading to damage in the small intestine.
Genetic testing has demonstrated that genes from the major histocompatibility complex (MHC II) region primarily contribute to genetic predisposition. It's estimated that this complex accounts for up to 40% of the genetic susceptibility to coeliac disease. However, the presence of these genes does not mean that coeliac disease will develop. Around 25–30% of the population carries this genetic makeup, yet only 1% of them are likely to develop the disease. Given that the vast majority of individuals with confirmed coeliac disease (99%) possess one of the DQ2/DQ8 alleles of the HLA system, this test proves valuable for ruling out a predisposition to coeliac disease. A negative test result means that it is virtually impossible for you to develop coeliac disease in your lifetime. [1].
What does the celiac disease test include?
The test monitors for the presence of genes associated with coeliac disease: HLA-DQ2 and HLA-DQ8.
Instructions before collection
Please, only make an appointment for the examination Blood test to detect colorectal cancer between Monday and Thursday. Please, also do not make an appointment for collection on days preceding public holidays. If you make an appointment on a Friday or on a day before a public holiday, we will contact you and your appointment will be changed to another date by mutual agreement.
The result of the genetic test is not affected by adherence to a gluten-free diet. Peripheral blood collection does not need to be performed while fasting and can be performed at any time of the day. The result of the test is not affected by the use of any medications, diets or smoking.
Sources
[1] Kaukinen K, Partanen J, Mäki M, Collin P. HLA-DQ typing in the diagnosis of celiac disease. Am J Gastroenterol 2002; 97:695.
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